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Article

ANGPTL3 Variants Associate with Lower Levels of Irisin and C-Peptide in a Cohort of Arab Individuals.

Genes - 17 May 2021

Alanbaei Muath, Abu-Farha Mohamed, Hebbar Prashantha, Melhem Motasem, Chandy Betty S, Anoop Emil, Cherian Preethi, Al-Khairi Irina, Alkayal Fadi, Al-Mulla Fahd, Abubaker Jehad, Thanaraj Thangavel Alphonse

Abstract excerpt

ANGPTL3 is an important regulator of lipid metabolism. Its inhibition in people with hypercholesteremia reduces plasma lipid levels dramatically. Genome-wide association studies have associated ANGPTL3 variants with lipid traits. Irisin, an exercise-modulated protein, has been associated with lipid metabolism. Intracellular accumulation of lipids impairs insulin action and contributes to metabolic disorders. In...

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Identifiers

PMID: 34067751
DOI: 10.3390/genes12050755
PMCID: PMC8170900

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