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Article

Dysfibrinogenemia-Potential Impact of Genotype on Thrombosis or Bleeding.

Seminars in thrombosis and hemostasis - 1 Mar 2022

Bor Mustafa Vakur, Feddersen Søren, Pedersen Inge Søkilde, Sidelmann Johannes Jakobsen, Kristensen Søren Risom

Abstract excerpt

The congenital dysfibrinogenemias, most often associated with bleeding disorders, encompass mutations in the amino-terminal end of fibrinogen α-chain consisting of Gly17-Pro18-Arg19-Val20, known as knob A, which is a critical site for fibrin polymerization. Here we review the studies reporting dysfibrinogenemia due to mutations affecting fibrinogen knob A and identified 29 papers. The number of reports on...

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Identifiers

PMID: 34261148
DOI: 10.1055/s-0041-1730358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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