Article
Detecting Mutations in the Mycobacterium tuberculosis Pyrazinamidase Gene pncA to Improve Infection Control and Decrease Drug Resistance Rates in Human Immunodeficiency Virus Coinfection.
The American journal of tropical medicine and hygiene - 7 Dec 2016
Dudley Matthew Z, Sheen Patricia, Gilman Robert H, Ticona Eduardo, Friedland Jon S, Kirwan Daniela E, Caviedes Luz, Rodriguez Richard, Cabrera Lilia Z, Coronel Jorge, Grandjean Louis, Moore David A J, Evans Carlton A, Huaroto Luz, Chávez-Pérez Víctor, Zimic Mirko
Abstract excerpt
Hospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)-positive patients, as these patients are at heightened risk of developing TB. Pyrazinamide (PZA) is a potent drug that effectively sterilizes persistent Mycobacterium tuberculosis bacilli. However, PZA resistance associated with mutations in the...
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