Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induced Chromosomal Proximity and Gene Fusions in Prostate Cancer

30 Oct 2009

Abstract excerpt

Gene fusions play a critical role in cancer progression. The mechanisms underlying their genesis and cell type specificity are not well understood. About 50% of human prostate cancers display a gene fusion involving the 5' untranslated region of TMPRSS2, an androgen-regulated gene, and the protein-coding sequences of ERG, which encodes an erythroblast transformation-specific (ETS) transcription factor. By...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Genomics and Chromatin Dynamics
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19933109
DOI: 10.1126/science.1178124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induced Chromosomal Proximity and Gene Fusions in Prostate CancerPMID 19933109Read ↗

ETS fusion genes in prostate cancerSemantic proximity Read ↗

Fusion in the ETS gene family and prostate cancerSemantic proximity Read ↗

The discovery and application of gene fusions in prostate cancer.Semantic proximity Read ↗

Androgen-Driven Fusion Genes and Chimeric Transcripts in Prostate CancerSemantic proximity Read ↗

TMPRSS2-ERG Gene Fusion Causing ERG Overexpression Precedes Chromosome Copy Number Changes in Prostate Carcinomas, Paired HGPIN LesionsSemantic proximity Read ↗

Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate CancerSemantic proximity Read ↗

[TMPRSS2-ETS gene fusion in prostate cancer].Semantic proximity Read ↗

Systematic analysis reveals molecular characteristics of ERG-negative prostate cancer.Semantic proximity Read ↗

ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor.Semantic proximity Read ↗

TMPRSS2-ERG Fusion Gene Expression in Prostate Tumor Cells and Its Clinical and Biological Significance in Prostate Cancer ProgressionSemantic proximity Read ↗

Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer.Semantic proximity Read ↗

Distinct genomic aberrations associated with ERG rearranged prostate cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.