Detailed Molecular and Immune Marker Profiling of Archival Prostate Cancer Samples Reveals an Inverse Association between TMPRSS2:ERG Fusion Status and Immune Cell Infiltration.

doi:10.1016/j.jmoldx.2020.02.012

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Article

Detailed Molecular and Immune Marker Profiling of Archival Prostate Cancer Samples Reveals an Inverse Association between TMPRSS2:ERG Fusion Status and Immune Cell Infiltration.

The Journal of molecular diagnostics : JMD - 1 May 2020

Rao Srinivasa R, Alham Nasullah K, Upton Elysia, McIntyre Stacey, Bryant Richard J, Cerundolo Lucia, Bowes Emma, Jones Stephanie, Browne Molly, Mills Ian, Lamb Alastair, Tomlinson Ian, Wedge David, Browning Lisa, Sirinukunwattana Korsuk, Palles Claire, Hamdy Freddie C, Rittscher Jens, Verrill Clare

Abstract excerpt

Prostate cancer is a significant global health issue, and limitations to current patient management pathways often result in overtreatment or undertreatment. New ways to stratify patients are urgently needed. We conducted a feasibility study of such novel assessments, looking for associations between genomic changes and lymphocyte infiltration. An innovative workflow using an in-house targeted sequencing panel,...

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PMID: 32229180
DOI: 10.1016/j.jmoldx.2020.02.012

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Detailed Molecular and Immune Marker Profiling of Archival Prostate Cancer Samples Reveals an Inverse Association between TMPRSS2:ERG Fusion Status and Immune Cell Infiltration.PMID 32229180Read ↗

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