Article
Suppression of endogenous IL-10 gene expression in dendritic cells enhances antigen presentation for specific Th1 induction: potential for cellular vaccine development.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2000
Igietseme J U, Ananaba G A, Bolier J, Bowers S, Moore T, Belay T, Eko F O, Lyn D, Black C M
Abstract excerpt
A new paradigm for designing vaccines against certain microbial pathogens, including Chlamydia trachomatis, is based on the induction of local mucosal Th1 response. IL-10 is an anti-inflammatory cytokine that exerts negative immunoregulatory influence on Th1 response. This study investigated whether biochemical modulation of endogenous IL-10 expression at the level of APCs is a practical strategy for enhancing...
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