Epigenetic analysis of the IFNλ3 gene identifies a novel marker for response to therapy in HCV-infected subjects.

doi:10.1111/jvh.12661

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Epigenetic analysis of the IFNλ3 gene identifies a novel marker for response to therapy in HCV-infected subjects.

Journal of viral hepatitis - 1 May 2017

Waring J F, Davis J W, Dumas E, Cohen D, Idler K, Abel S, Georgantas R, Podsadecki T, Dutta S

Abstract excerpt

Chronic hepatitis C virus (HCV) infection is characterized by high interindividual variability in response to pegylated interferon and ribavirin. A genetic polymorphism on chromosome 19 (rs12979860) upstream of interferon-λ3 (IFNλ3) is associated with a twofold change in sustained virologic response rate after 48 weeks of treatment with pegylated interferon/ribavirin in HCV genotype 1 (GT1) treatment-naïve...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclopropanes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferons

Share to Interleukins

Share to Lactams, Macrocyclic

Share to Macrocyclic Compounds

Share to Proline

Share to Sulfonamides

Share to Treatment Failure

Source

Open in PubMed

Identifiers

PMID: 27925355
DOI: 10.1111/jvh.12661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic analysis of the IFNλ3 gene identifies a novel marker for response to therapy in HCV-infected subjects.PMID 27925355Read ↗

Association of IFNL3 rs12979860 and rs8099917 with biochemical predictors of interferon responsiveness in chronic hepatitis C virus infection.Semantic proximity Read ↗

Interferon Lambda-3 rs12979860 Variants and Response to Pegylated Interferon in Chronic Hepatitis-C Genotype-3.Semantic proximity Read ↗

Association between IFN-λ 3 Gene Polymorphisms and Outcome of Treatment with Direct Acting Antivirals in Chronic HCV-Infected Egyptian Patients.Semantic proximity Read ↗

Pervasive Adaptation of Hepatitis C Virus to Interferon Lambda Polymorphism Across Multiple GenotypesSemantic proximity Read ↗

Interferon lambdas: the next cytokine storm.Semantic proximity Read ↗

Interferon drives HCV scarring of the epigenome and creates targetable vulnerabilities following viral clearanceSemantic proximity Read ↗

IFNL3 polymorphisms predict response to therapy in chronic hepatitis C genotype 2/3 infection.Semantic proximity Read ↗

The Impact of interferon lambda 3 Polymorphism on Hepato-Cellular Carcinoma Progression in Hepatitis C Virus Patients: Treatment-Naïve and Experienced.Semantic proximity Read ↗

IFNL3/4 genotype is associated with altered immune cell populations in peripheral blood in chronic hepatitis C infection.Semantic proximity Read ↗

The relationships between IFNL4 genotype, intrahepatic interferon-stimulated gene expression and interferon treatment response differs in HCV-1 compared with HCV-3.Semantic proximity Read ↗

Interferon lambda-3 polymorphism and response to pegylated interferon in patients with hepatitis D.Semantic proximity Read ↗

Interferon λ 3 and 4 Genotyping Using High-Resolution Melt Curve Analysis Suitable for Multiple Clinical Sample Types.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.