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Article

Establishment and Long-Term Expansion of Small Cell Lung Cancer Patient-Derived Tumor Organoids

29 Jan 2021

Abstract excerpt

Differential chemo-sensitivity of cancer cells, which is attributed to the cellular heterogeneity and phenotypic variation of cancer cells, is considered to be the main reason for tumor recurrence after chemotherapy. Here, we generated small cell lung cancer patient-derived tumor organoids and subjected them to long-term expansion with the addition of WNT3A or R-spondin1. We confirmed that the organoids have...

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PMID: 33572899
DOI: 10.3390/ijms22031349

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