In silico analysis reveals PRDX4 as a prognostic and oncogenic marker in renal papillary cell carcinoma

Abstract excerpt

BACKGROUND: Alterations in the tumor microenvironment leads to the accumulation of reactive oxygen species (ROS). When in low levels, ROS act as a signaling molecule and contribute to tumor cell proliferation whereas its elevation results in oxidative stress and eventually cell death. It is known that antioxidant systems regulate the ROS levels and thus cell fate. Among these systems, peroxiredoxins (PRDXs) were...

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