Article
Cross-protection against Vibrio cholerae infection by monoclonal antibodies against Vibrio vulnificus RtxA1/MARTXVv.
Microbiology and immunology - 1 Nov 2016
Lee Tae Hee, Cha Sun-Shin, Lee Chang-Seop, Rhee Joon Haeng, Woo Hye Ryun, Chung Kyung Min
Abstract excerpt
Gram-negative Vibrio species secrete multifunctional autoprocessing repeats-in-toxin (MARTX) toxins associated with bacterial pathogenesis. Here, the cross-reactivity and cross-protectivity of mAbs against V. vulnificus RtxA1/MARTXVv was evaluated. Passive administration of any of these mAbs (21RA, 24RA, 46RA, 47RA and 50RA) provided strong protection against lethal V. cholerae infection. Interestingly, 24RA and...
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