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A Chlamydia trachomatis VD1-MOMP vaccine elicits cross-neutralizing and protective antibodies against C/C-related complex serovars

19 Apr 2021

Abstract excerpt

Abstract Ocular and urogenital infections withChlamydia trachomatis (C.t.) are caused by a range of different serovars. The firstC.t. vaccine in clinical development (CTH522/CAF®01) induced neutralizing antibodies directed to the variable domain 4 (VD4) region of major outer membrane protein (MOMP), covering predominantly B and intermediate groups of serovars. The VD1 region of MOMP contains neutralizing B-cell...

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PMID: 33875654
DOI: 10.1038/s41541-021-00312-9

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