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Article

Long-Term Protection of Genetically Ablated Rabbit Retinal Degeneration by Sustained Transscleral Unoprostone Delivery.

Investigative ophthalmology & visual science - 1 Dec 2016

Nagai Nobuhiro, Koyanagi Eri, Izumida Yasuko, Liu Junjun, Katsuyama Aya, Kaji Hirokazu, Nishizawa Matsuhiko, Osumi Noriko, Kondo Mineo, Terasaki Hiroko, Mashima Yukihiko, Nakazawa Toru, Abe Toshiaki

Abstract excerpt

Purpose: To evaluate the long-term protective effects of transscleral unoprostone (UNO) against retinal degeneration in transgenic (Tg) rabbits (Pro347Leu rhodopsin mutation). Methods: The UNO release devices (URDs) were implanted into the sclerae of Tg rabbits and ERG, optical coherence tomography (OCT), and ophthalmic examinations were conducted for 40 weeks. Unoprostone metabolites in retina, choroid/RPE,...

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PMID: 27918826
DOI: 10.1167/iovs.16-20453

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ERG
RPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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