Article
Protective effects of sustained transscleral unoprostone delivery against retinal degeneration in S334ter rhodopsin mutant rats.
Journal of biomedical materials research. Part B, Applied biomaterials - 1 Nov 2016
Nagai Nobuhiro, Iwata Satoru, Kaji Hirokazu, Sampei Kaori, Katsukura Yuki, Onami Hideyuki, Nishizawa Matsuhiko, Nakazawa Toru, Mashima Yukihiko, Abe Toshiaki
Abstract excerpt
It has been suggested that unoprostone isopropyl (UNO) has potent neuroprotective activity in the retina. The effect of sustained transscleral UNO delivery to the posterior segment of the eye on photoreceptor degeneration was evaluated. UNO was loaded into a device made of poly(ethyleneglycol) dimethacrylate by polydimethylsiloxane mold-based UV-curing. The amount of UNO diffusing from these devices was measured...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.