Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered cytokine profile, pain sensitivity, and stress responsivity in mice with co-disruption of the developmental genes Neuregulin-1×DISC1.

Behavioural brain research - 1 Mar 2017

Desbonnet Lieve, Cox Rachel, Tighe Orna, Lai Donna, Harvey Richard P, Waddington John L, O'Tuathaigh Colm M P

Abstract excerpt

The complex genetic origins of many human disorders suggest that epistatic (gene×gene) interactions may contribute to a significant proportion of their heritability estimates and phenotypic heterogeneity. Simultaneous disruption of the developmental genes and schizophrenia risk factors Neuregulin-1 (NRG1) and Disrupted-in-schizophrenia 1 (DISC1) in mice has been shown to produce disease-relevant and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Ocular
Share to Analysis of Variance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperalgesia

Share to Neuregulin-1

Share to Pain Measurement

Share to Pain Threshold

Share to Stress, Psychological

Source

Identifiers

PMID: 27916686
DOI: 10.1016/j.bbr.2016.11.049

Genes

NRG1
DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered cytokine profile, pain sensitivity, and stress responsivity in mice with co-disruption of the developmental genes Neuregulin-1×DISC1.PMID 27916686Read ↗

Social defeat interacts with Disc1 mutations in the mouse to affect behavior.Semantic proximity Read ↗

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.Semantic proximity Read ↗

Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice.Semantic proximity Read ↗

Gene models of schizophrenia: DISC1 mouse models.Semantic proximity Read ↗

Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1.Semantic proximity Read ↗

Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice.Semantic proximity Read ↗

Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.Semantic proximity Read ↗

Behavioral phenotypes in schizophrenic animal models with multiple combinations of genetic and environmental factors.Semantic proximity Read ↗

Disc1 variation leads to specific alterations in adult neurogenesis.Semantic proximity Read ↗

Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders.Semantic proximity Read ↗

Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia.Semantic proximity Read ↗

Phenotypic characterization of C57BL/6J mice carrying the Disc1 gene from the 129S6/SvEv strain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.