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Article

Impact of the HIV Tat C30C31S dicysteine substitution on neuropsychological function in patients with clade C disease.

Journal of neurovirology - 1 Dec 2014

Paul Robert H, Joska John A, Woods Carol, Seedat Soraya, Engelbrecht Susan, Hoare Jacqueline, Heaps Jodi, Valcour Victor, Ances Beau, Baker Laurie M, Salminen Lauren E, Stein Dan J

Abstract excerpt

Previous animal studies have identified a C31S residue substitution in the C30C31 dicysteine motif of the Tat protein that is associated with reduced neurovirulence in clade C human immunodeficiency virus (HIV). However, clinical studies of patients infected with clade C HIV have reported significant levels of cognitive impairment. To date, no study has specifically examined cognitive function in clade C-infected...

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Identifiers

PMID: 25366660
DOI: 10.1007/s13365-014-0293-z
PMCID: PMC4268069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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