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Article

Purification and Crystallization of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

10 Jul 2004

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) is a membrane protein that is mutated in patients suffering from cystic fibrosis. Here we report the purification and first crystallization of wild-type human CFTR. Functional characterization of the material showed it to be highly active. Electron crystallography of negatively stained two-dimensional crystals of CFTR has revealed the overall...

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PMID: 15247233
DOI: 10.1074/jbc.m407434200

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