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Zika virus cell tropism in the developing human brain and inhibition by azithromycin

29 Nov 2016

Abstract excerpt

The rapid spread of Zika virus (ZIKV) and its association with abnormal brain development constitute a global health emergency. Congenital ZIKV infection produces a range of mild to severe pathologies, including microcephaly. To understand the pathophysiology of ZIKV infection, we used models of the developing brain that faithfully recapitulate the tissue architecture in early to midgestation. We identify the...

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PMID: 27911847
DOI: 10.1073/pnas.1618029113

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