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Genome-wide CRISPR screen for Zika virus resistance in human neural cells

24 Apr 2019

Abstract excerpt

Zika virus (ZIKV) is a neurotropic and neurovirulent arbovirus that has severe detrimental impact on the developing human fetal brain. To date, little is known about the factors required for ZIKV infection of human neural cells. We identified ZIKV host genes in human pluripotent stem cell (hPSC)-derived neural progenitors (NPs) using a genome-wide CRISPR-Cas9 knockout screen. Mutations of host factors involved in...

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PMID: 31019072
DOI: 10.1073/pnas.1900867116

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