Article
Amyloid-β peptide induces mitochondrial dysfunction by inhibition of preprotein maturation.
Cell metabolism - 7 Oct 2014
Mossmann Dirk, Vögtle F-Nora, Taskin Asli Aras, Teixeira Pedro Filipe, Ring Julia, Burkhart Julia M, Burger Nils, Pinho Catarina Moreira, Tadic Jelena, Loreth Desiree, Graff Caroline, Metzger Friedrich, Sickmann Albert, Kretz Oliver, Wiedemann Nils, Zahedi René P, Madeo Frank, Glaser Elzbieta, Meisinger Chris
Abstract excerpt
Most mitochondrial proteins possess N-terminal presequences that are required for targeting and import into the organelle. Upon import, presequences are cleaved off by matrix processing peptidases and subsequently degraded by the peptidasome Cym1/PreP, which also degrades Amyloid-beta peptides (Aβ). Here we find that impaired turnover of presequence peptides results in feedback inhibition of presequence...
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