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Article

Cdk5 Directly Targets Nuclear p21CIP1 and Promotes Cancer Cell Growth

30 Nov 2016

Abstract excerpt

Abstract The significance of Cdk5 in cell-cycle control and cancer biology has gained increased attention. Here we report the inverse correlation between the protein levels of Cdk5 and p21CIP1 from cell-based and clinical analysis. Mechanistically, we identify that Cdk5 overexpression triggers the proteasome-dependent degradation of p21CIP1 through a S130 phosphorylation in a Cdk2-independent manner. Besides, the...

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PMID: 27909065
DOI: 10.1158/0008-5472.can-15-3253

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