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Article

Prepore Stability Controls Productive Folding of the BAM-independent Multimeric Outer Membrane Secretin PulD.

The Journal of biological chemistry - 6 Jan 2017

Guilvout Ingrid, Brier Sébastien, Chami Mohamed, Hourdel Véronique, Francetic Olivera, Pugsley Anthony P, Chamot-Rooke Julia, Huysmans Gerard H M

Abstract excerpt

Members of a group of multimeric secretion pores that assemble independently of any known membrane-embedded insertase in Gram-negative bacteria fold into a prepore before membrane-insertion occurs. The mechanisms and the energetics that drive the folding of these proteins are poorly understood. Here, equilibrium unfolding and hydrogen/deuterium exchange monitored by mass spectrometry indicated that a loss of 4-5...

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Identifiers

PMID: 27903652
DOI: 10.1074/jbc.M116.759498
PMCID: PMC5217691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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