Article
Competing stress-dependent oligomerization pathways regulate self-assembly of the periplasmic protease-chaperone DegP.
Proceedings of the National Academy of Sciences of the United States of America - 10 Aug 2021
Harkness Robert W, Toyama Yuki, Ripstein Zev A, Zhao Huaying, Sever Alexander I M, Luan Qing, Brady Jacob P, Clark Patricia L, Schuck Peter, Kay Lewis E
Abstract excerpt
DegP is an oligomeric protein with dual protease and chaperone activity that regulates protein homeostasis and virulence factor trafficking in the periplasm of gram-negative bacteria. A number of oligomeric architectures adopted by DegP are thought to facilitate its function. For example, DegP can form a "resting" hexamer when not engaged to substrates, mitigating undesired proteolysis of cellular proteins. When...
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