Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequence diversity of dengue virus type 2 in brain and thymus of infected interferon receptor ko mice: implications for dengue virulence.

Virology journal - 30 Nov 2016

Dhole Priya, Nakayama Emi E, Saito Akatsuki, Limkittikul Kriengsak, Phanthanawiboon Supranee, Shioda Tatsuo, Kurosu Takeshi

Abstract excerpt

BACKGROUND: We previously reported that a clinical isolate of dengue virus (DENV) is capable of causing acute-phase systemic infection in mice harboring knockouts of the genes encoding type-I and -II interferon IFN receptors (IFN-α/β/γR KO mice); in contrast, other virulent DENV isolates exhibited slow disease progression in this mice, yielding lethal infection around 20 days post-infection (p.i.). In the present...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Dengue

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dengue Virus

Share to Genome, Viral

Share to Receptors, Interferon

Share to Survival Analysis

Share to Thymus Gland

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 27903277
DOI: 10.1186/s12985-016-0658-4
PMCID: PMC5129197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequence diversity of dengue virus type 2 in brain and thymus of infected interferon receptor ko mice: implications for dengue virulence.PMID 27903277Read ↗

Characterization of a model of lethal dengue virus 2 infection in C57BL/6 mice deficient in the alpha/beta interferon receptor.Semantic proximity Read ↗

Brain transcriptomics reveals features of the host response after dengue virus type I infection induced central nervous system injury in AGB6 miceSemantic proximity Read ↗

Murine Model for Dengue Virus-Induced Lethal Disease with IncreasedVascular PermeabilitySemantic proximity Read ↗

Deep spatial profiling of Venezuelan equine encephalitis virus reveals increased genetic diversity amidst neuroinflammation and cell death during brain infection.Semantic proximity Read ↗

Tracking the evolution of dengue virus strains D2S10 and D2S20 by 454 pyrosequencing.Semantic proximity Read ↗

STAT2 Mediates Innate Immunity to Dengue Virus in the Absence of STAT1 via the Type I Interferon ReceptorSemantic proximity Read ↗

Humanized mice show clinical signs of dengue fever according to infecting virus genotype.Semantic proximity Read ↗

Rapid accumulation of virulent rift valley Fever virus in mice from an attenuated virus carrying a single nucleotide substitution in the m RNA.Semantic proximity Read ↗

Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor knockout (A129) miceSemantic proximity Read ↗

Expression profiling of lymph node cells from deer mice infected with Andes virusSemantic proximity Read ↗

Neurovirulence of the Australian outbreak Japanese Encephalitis virus genotype 4 is lower compared to genotypes 2 and 3 in mice and human cortical brain organoidsSemantic proximity Read ↗

An IRF-3-, IRF-5-, and IRF-7-Independent Pathway of Dengue Viral Resistance Utilizes IRF-1 to Stimulate Type I and II Interferon ResponsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.