Article
Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus.
Journal of virology - 1 Aug 1995
Piccone M E, Zellner M, Kumosinski T F, Mason P W, Grubman M J
Abstract excerpt
The foot-and-mouth disease virus (FMDV) leader (L) protein is involved in autocatalytic cleavage at the L/P1 junction and in the cleavage of translation initiation factor p220, a subunit of the cap-binding protein complex. It has been suggested that this proteinase has homology to the papain-like family of cysteine proteinases, and from this information, we have investigated the active-site residues by...
Topics
- Animals
- Aphthovirus
- Binding Sites
- Catalysis
- Cell Line
- Cloning, Molecular
- Cricetinae
- Endopeptidases
- Escherichia coli
- Mutation
- Protein Processing, Post-Translational