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Article

Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus.

Journal of virology - 1 Aug 1995

Piccone M E, Zellner M, Kumosinski T F, Mason P W, Grubman M J

Abstract excerpt

The foot-and-mouth disease virus (FMDV) leader (L) protein is involved in autocatalytic cleavage at the L/P1 junction and in the cleavage of translation initiation factor p220, a subunit of the cap-binding protein complex. It has been suggested that this proteinase has homology to the papain-like family of cysteine proteinases, and from this information, we have investigated the active-site residues by...

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Identifiers

PMID: 7609064
DOI: 10.1128/JVI.69.8.4950-4956.1995
PMCID: PMC189310

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