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Article

Poly(A)-specific ribonuclease regulates the processing of small-subunit rRNAs in human cells.

Nucleic acids research - 7 Apr 2017

Ishikawa Hideaki, Yoshikawa Harunori, Izumikawa Keiichi, Miura Yutaka, Taoka Masato, Nobe Yuko, Yamauchi Yoshio, Nakayama Hiroshi, Simpson Richard J, Isobe Toshiaki, Takahashi Nobuhiro

Abstract excerpt

Ribosome biogenesis occurs successively in the nucleolus, nucleoplasm, and cytoplasm. Maturation of the ribosomal small subunit is completed in the cytoplasm by incorporation of a particular class of ribosomal proteins and final cleavage of 18S-E pre-rRNA (18S-E). Here, we show that poly(A)-specific ribonuclease (PARN) participates in steps leading to 18S-E maturation in human cells. We found PARN as a novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27899605
DOI: 10.1093/nar/gkw1047
PMCID: PMC5389690

Genes

PARN
LTV1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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