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Article

Human fetal and adult epicardial-derived cells: a novel model to study their activation

29 Nov 2016

Abstract excerpt

BACKGROUND: The epicardium, a cell layer covering the heart, plays an important role during cardiogenesis providing cardiovascular cell types and instructive signals, but becomes quiescent during adulthood. Upon cardiac injury the epicardium is activated, which includes induction of a developmental gene program, epithelial-to-mesenchymal transition (EMT) and migration. However, the response of the adult...

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PMID: 27899163
DOI: 10.1186/s13287-016-0434-9

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