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Regulation of Epicardial Cell Fate during Cardiac Development and Disease: An Overview

16 Mar 2022

Abstract excerpt

The epicardium is the outermost cell layer in the vertebrate heart that originates during development from mesothelial precursors located in the proepicardium and septum transversum. The epicardial layer plays a key role during cardiogenesis since a subset of epicardial-derived cells (EPDCs) undergo an epithelial-mesenchymal transition (EMT); migrate into the myocardium; and differentiate into distinct cell...

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PMID: 35328640
DOI: 10.3390/ijms23063220

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