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Multicenter prospective study of angiogenesis polymorphism validation in HCC patients treated with sorafenib. An INNOVATE study protocol.

Tumori - 1 Dec 2018

Gardini Andrea Casadei, Faloppi Luca, Aprile Giuseppe, Brunetti Oronzo, Caparello Chiara, Corbelli Jody, Chessa Luchino, Bruno Daniele, Ercolani Giorgio, Leonetti Alessandro, Stefano Giorgio de, Farella Nunzia, Foschi Francesco Giuseppe, Lanzi Arianna, Dadduzio Vincenzo, Marisi Giorgia, Masi Gianluca, Negri Francesca V, Pagan Flavia, Santini Daniele, Scarpi Emanuela, Silletta Marianna, Silvestris Nicola, Tamburini Emiliano, Tassinari Davide, Vivaldi Caterina, Gentilucci Umberto Vespasiani, Zagonel Vittorina, Calvetti Lorenzo, Cascinu Stefano, Frassineti Giovanni Luca, Scartozzi Mario

Abstract excerpt

INTRODUCTION: Although sorafenib is the upfront standard of care for advanced hepatocellular carcinoma (HCC), molecular predictors of efficacy have not been identified yet. In the ALICE-1 study, rs2010963 of VEGF-A and VEGF-C proved to be independent predictive factors for progression-free survival (PFS) and overall survival (OS) in multivariate analysis. The ALICE-1 study results were confirmed in the ALICE-2...

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PMID: 29739298
DOI: 10.5301/tj.5000704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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