Article
Genetic and epigenetic profiling indicates the proximal tubule origin of renal cancers in end-stage renal disease.
Cancer science - 1 Nov 2020
Ishihara Hiroki, Yamashita Satoshi, Liu Yu-Yu, Hattori Naoko, El-Omar Omar, Ikeda Takashi, Fukuda Hironori, Yoshida Kazuhiko, Takagi Toshio, Taneda Sekiko, Kondo Tsunenori, Nagashima Yoji, Tanabe Kazunari, Ushijima Toshikazu
Abstract excerpt
End-stage renal disease (ESRD) patients on dialysis therapy have a higher incidence of renal cell carcinomas (RCCs), which consist of 2 major histopathological types: clear-cell RCCs (ESRD-ccRCCs) and acquired cystic disease (ACD)-associated RCCs. However, their genetic and epigenetic alterations are still poorly understood. Here, we investigated somatic mutations, copy number alterations (CNAs), and DNA...
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