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Article

Xenogeneic Mitochondrial Transplantation Improves Selected Age-Associated Phenotypes in Mice.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Aug 2026

Li Wenpeng, Wang Xijia, Hu Yaning, Yang Zhen, Niu Tian, Zhao Xingbo

Abstract excerpt

Xenogeneic mitochondrial transplantation (xeno-MT) improves selected age-associated phenotypes and mitochondrial functional readouts in mice while engaging host mitochondrial quality-control-related pathways. Donor mitochondrial preparations with impaired membrane potential retained measurable activity, but both respiratory competence and in vivo efficacy declined progressively with more extensive...

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PMID: 42171348
DOI: 10.1002/advs.75806
PMCID: PMC13336034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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