Article
Vitamin K epoxide reductase expression and prostate cancer risk.
Urologic oncology - 1 Mar 2017
Tew Ben Yi, Pal Sumanta K, He Miaoling, Tong Tommy, Wu Huiqing, Hsu JoAnn, Liu Xueli, Neuhausen Susan L, Jones Jeremy O
Abstract excerpt
PURPOSE: Increasing evidence has demonstrated that men taking the anticoagulant warfarin have a lower risk of developing prostate cancer. This phenomenon is not observed in other cancers. We sought to determine if the target of warfarin, vitamin K epoxide reductase (VKOR), is expressed in benign and cancerous prostate tissues and if a functional single nucleotide polymorphism (SNP) in the VKOR gene is associated...
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