Article
Evidence for the differential expression of a variant EGF receptor protein in human prostate cancer.
British journal of cancer - 1 Jan 2000
Olapade-Olaopa E O, Moscatello D K, MacKay E H, Horsburgh T, Sandhu D P, Terry T R, Wong A J, Habib F K
Abstract excerpt
Earlier studies have demonstrated an unexplained depletion of the epidermal growth factor receptor (EGFR) protein expression in prostatic cancer. We now attribute this phenomenon to the presence of a variant EGFR (EGFRvIII) that is highly expressed in malignant prostatic neoplasms. In a retrospective study, normal, benign hyperplastic and malignant prostatic tissues were examined at the mRNA and protein levels...
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