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Article

mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety.

Cell reports - 22 Nov 2016

Deguchi Yuichi, Harada Masaya, Shinohara Ryota, Lazarus Michael, Cherasse Yoan, Urade Yoshihiro, Yamada Daisuke, Sekiguchi Masayuki, Watanabe Dai, Furuyashiki Tomoyuki, Narumiya Shuh

Abstract excerpt

Here, we show neuronal inactivation-induced presynaptic remodeling and involvement of the mammalian homolog of Diaphanous (mDia) and Rho-associated coiled-coil-containing kinase (ROCK), Rho-regulated modulators of actin and myosin, in this process. We find that social isolation induces inactivation of nucleus accumbens (NAc) neurons associated with elevated anxiety-like behavior, and that mDia in NAc neurons is...

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PMID: 27880913
DOI: 10.1016/j.celrep.2016.10.088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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