Article

Inherited human TFIIIA deficiency disrupts T cell development

2026-07-01

Abstract excerpt

<h4>ABSTRACT</h4> Molecular characterization of human monogenic inborn errors of T cell immunity provides both biological insights and medical progress. We report rare biallelic deleterious variants in GTF3A , encoding transcription factor IIIA (TFIIIA), a zinc-finger protein required for transcription and chaperoning of 5S ribosomal RNA (rRNA). These variants were identified in ten patients from eight unrelated...

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Literature Corpus work: ca1c8da6-6c8b-58e8-9b09-07ab4c0430d3
DOI: 10.64898/2026.07.01.26356670

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