Article
Genetic Variation in the SLC8A1 Calcium Signaling Pathway Is Associated With Susceptibility to Kawasaki Disease and Coronary Artery Abnormalities.
Circulation. Cardiovascular genetics - 1 Dec 2016
Shimizu Chisato, Eleftherohorinou Hariklia, Wright Victoria J, Kim Jihoon, Alphonse Martin P, Perry James C, Cimaz Rolando, Burgner David, Dahdah Nagib, Hoang Long T, Khor Chiea Chuen, Salgado Andrea, Tremoulet Adriana H, Davila Sonia, Kuijpers Taco W, Hibberd Martin L, Johnson Todd A, Takahashi Atsushi, Tsunoda Tatsuhiko, Kubo Michiaki, Tanaka Toshihiro, Onouchi Yoshihiro, Yeung Rae S M, Coin Lachlan J M, Levin Michael, Burns Jane C
Abstract excerpt
BACKGROUND: Kawasaki disease (KD) is an acute pediatric vasculitis in which host genetics influence both susceptibility to KD and the formation of coronary artery aneurysms. Variants discovered by genome-wide association studies and linkage studies only partially explain the influence of genetics on KD susceptibility. METHODS AND RESULTS: To search for additional functional genetic variation, we performed pathway...
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