Article
Variations in ORAI1 Gene Associated with Kawasaki Disease.
PloS one - 1 Jan 2016
Onouchi Yoshihiro, Fukazawa Ryuji, Yamamura Kenichiro, Suzuki Hiroyuki, Kakimoto Nobuyuki, Suenaga Tomohiro, Takeuchi Takashi, Hamada Hiromichi, Honda Takafumi, Yasukawa Kumi, Terai Masaru, Ebata Ryota, Higashi Kouji, Saji Tsutomu, Kemmotsu Yasushi, Takatsuki Shinichi, Ouchi Kazunobu, Kishi Fumio, Yoshikawa Tetsushi, Nagai Toshiro, Hamamoto Kunihiro, Sato Yoshitake, Honda Akihito, Kobayashi Hironobu, Sato Junichi, Shibuta Shoichi, Miyawaki Masakazu, Oishi Ko, Yamaga Hironobu, Aoyagi Noriyuki, Yoshiyama Megumi, Miyashita Ritsuko, Murata Yuji, Fujino Akihiro, Ozaki Kouichi, Kawasaki Tomisaku, Abe Jun, Seki Mitsuru, Kobayashi Tohru, Arakawa Hirokazu, Ogawa Shunichi, Hara Toshiro, Hata Akira, Tanaka Toshihiro
Abstract excerpt
Kawasaki disease (KD; MIM#61175) is a systemic vasculitis syndrome with unknown etiology which predominantly affects infants and children. Recent findings of susceptibility genes for KD suggest possible involvement of the Ca(2+)/NFAT pathway in the pathogenesis of KD. ORAI1 is a Ca(2+) release activated Ca(2+) (CRAC) channel mediating store-operated Ca(2+) entry (SOCE) on the plasma membrane. The gene for ORAI1...
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