Article
A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease.
PLoS genetics - 1 Jan 2009
Burgner David, Davila Sonia, Breunis Willemijn B, Ng Sarah B, Li Yi, Bonnard Carine, Ling Ling, Wright Victoria J, Thalamuthu Anbupalam, Odam Miranda, Shimizu Chisato, Burns Jane C, Levin Michael, Kuijpers Taco W, Hibberd Martin L
Abstract excerpt
Kawasaki disease (KD) is a pediatric vasculitis that damages the coronary arteries in 25% of untreated and approximately 5% of treated children. Epidemiologic data suggest that KD is triggered by unidentified infection(s) in genetically susceptible children. To investigate genetic determinants of KD susceptibility, we performed a genome-wide association study (GWAS) in 119 Caucasian KD cases and 135 matched...
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