Article
Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans.
Molecular neurobiology - 1 Dec 2017
Dong Jing, Wyss Annah, Yang Jingyun, Price T Ryan, Nicolas Aude, Nalls Michael, Tranah Greg, Franceschini Nora, Xu Zongli, Schulte Claudia, Alonso Alvaro, Cummings Steven R, Fornage Myriam, Zaykin Dmitri, Li Leping, Huang Xuemei, Kritchevsky Stephen, Liu Yongmei, Gasser Thomas, Wilson Robert S, De Jager Philip L, Singleton Andrew B, Pinto Jayant M, Harris Tamara, Mosley Thomas H, Bennett David A, London Stephanie, Yu Lei, Chen Honglei
Abstract excerpt
The human sense of smell decreases with age, and a poor sense of smell are among the most important prodromal symptoms of several neurodegenerative diseases. Recent evidence further suggests a racial difference in the sense of smell among U.S. older adults. However, no genome-wide association study (GWAS) on the sense of smell has been conducted in African-Americans (AAs). We performed the first genome-wide...
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