Article
Immunomodulatory effects of OX40Ig gene-modified adipose tissue-derived mesenchymal stem cells on rat kidney transplantation.
International journal of molecular medicine - 1 Jan 2017
Liu Tao, Zhang Yue, Shen Zhongyang, Zou Xunfeng, Chen Xiaobo, Chen Li, Wang Yuliang
Abstract excerpt
Recent studies have suggested that adipose tissue-derived mesenchymal stem cell (ADSC) therapy and OX40 costimulation blockade are two immunomodulatory strategies used to suppress the immune response to alloantigens. However, relatively little has been reported regarding the immunomodulatory potential of the abilityof these two strategies to synergize. Thus, in the present study, we aimed to investigate OX40-Ig...
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