Article
Immunomodulatory Effects of Different Cellular Therapies of Bone Marrow Origin on Chimerism Induction and Maintenance Across MHC Barriers in a Face Allotransplantation Model.
Archivum immunologiae et therapiae experimentalis - 1 Aug 2016
Hivelin Mikael, Klimczak Aleksandra, Cwykiel Joanna, Sonmez Erhan, Nasir Serdar, Gatherwright James, Siemionow Maria
Abstract excerpt
Many more patients would benefit from vascularized composite allotransplantation if less toxic and safer immunosuppressive protocols will become available. Tolerance induction protocols with donor cells co-transplantation are one of the promising pathways to reduce maintenance immunosupressive regimens. We investigated the role of donor bone marrow cells (BMC), mesenchymal stromal cells (MSC) and in vivo created...
Topics
- Animals
- Biopsy
- Bone Marrow
- Bone Marrow Cells
- Cell Movement
- Cell Survival
- Chimerism
- Face
- Facial Transplantation
- Flow Cytometry
- Graft Rejection
- Graft Survival
- Immunosuppression Therapy