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Article

Single-Nucleotide Polymorphisms of Genes Involved in Repair of Oxidative DNA Damage and the Risk of Recurrent Depressive Disorder.

Medical science monitor : international medical journal of experimental and clinical research - 20 Nov 2016

Czarny Piotr, Kwiatkowski Dominik, Toma Monika, Gałecki Piotr, Orzechowska Agata, Bobińska Kinga, Bielecka-Kowalska Anna, Szemraj Janusz, Berk Michael, Anderson George, Śliwiński Tomasz

Abstract excerpt

BACKGROUND Depressive disorder, including recurrent type (rDD), is accompanied by increased oxidative stress and activation of inflammatory pathways, which may induce DNA damage. This thesis is supported by the presence of increased levels of DNA damage in depressed patients. Such DNA damage is repaired by the base excision repair (BER) pathway. BER efficiency may be influenced by polymorphisms in BER-related...

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Source

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Identifiers

PMID: 27866211
DOI: 10.12659/msm.898091
PMCID: PMC5119689

Genes

LIG3
APEX1
FEN1
LIG1
PARP1
XRCC1

Variants

rs174538
rs1760944
rs1799782
rs1136410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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