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Article

Impact of Single Nucleotide Polymorphisms of Base Excision Repair Genes on DNA Damage and Efficiency of DNA Repair in Recurrent Depression Disorder.

Molecular neurobiology - 1 Aug 2017

Czarny Piotr, Kwiatkowski Dominik, Toma Monika, Kubiak Joanna, Sliwinska Agnieszka, Talarowska Monika, Szemraj Janusz, Maes Michael, Galecki Piotr, Sliwinski Tomasz

Abstract excerpt

Elevated level of DNA damage was observed in patients with depression. Furthermore, single nucleotide polymorphisms (SNPs) of base excision repair (BER) genes may modulate the risk of this disease. Therefore, the aim of this study was to delineate the association between DNA damage, DNA repair, the presence of polymorphic variants of BER genes, and occurrence of depression. The study was conducted on peripheral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27324896
DOI: 10.1007/s12035-016-9971-6
PMCID: PMC5509815

Genes

APEX1
XRCC1
LIG3
MUTYH
PARP1

Variants

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