Article
Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case-control study. The HUNT Study.
DNA repair - 1 Apr 2015
Skarpengland Tonje, Laugsand Lars Erik, Janszky Imre, Luna Luisa, Halvorsen Bente, Platou Carl G P, Wang Wei, Vatten Lars J, Damås Jan Kristian, Aukrust Pål, Bjørås Magnar, Åsvold Bjørn O
Abstract excerpt
BACKGROUND: Enhanced generation of reactive oxygen species and increased oxidative-induced DNA damage have been identified as possible contributors to atherosclerosis. The base excision repair (BER) pathway is the principal mechanism by which mammalian cells repair oxidative DNA damage. BER deficiency can potentially accelerate atherogenesis. METHODS: We evaluated the association of Single Nucleotide...
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