Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults.

doi:10.1093/ije/dyw245

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Article

Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults.

International journal of epidemiology - 1 Aug 2017

Varga Tibor V, Kurbasic Azra, Aine Mattias, Eriksson Pontus, Ali Ashfaq, Hindy George, Gustafsson Stefan, Luan Jian'an, Shungin Dmitry, Chen Yan, Schulz Christina-Alexandra, Nilsson Peter M, Hallmans Göran, Barroso Inês, Deloukas Panos, Langenberg Claudia, Scott Robert A, Wareham Nicholas J, Lind Lars, Ingelsson Erik, Melander Olle, Orho-Melander Marju, Renström Frida, Franks Paul W

Abstract excerpt

Background: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term changes in blood lipids. Methods: Participants from the GLACIER Study (Nmax = 3492) were genotyped with the MetaboChip array, from which 29 387 SNPs (single nucleotide polymorphisms; replication,...

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Identifiers

PMID: 27864399
DOI: 10.1093/ije/dyw245
PMCID: PMC5837581

Genes

CAD
APOE
APOA1
CAPN3
DOCK7
HPR
KCNIP1
SIX5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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