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Article

Genetic determinants of long-term changes in blood lipid concentrations: 10-year follow-up of the GLACIER study.

PLoS genetics - 1 Jun 2014

Varga Tibor V, Sonestedt Emily, Shungin Dmitry, Koivula Robert W, Hallmans Göran, Escher Stefan A, Barroso Inês, Nilsson Peter, Melander Olle, Orho-Melander Marju, Renström Frida, Franks Paul W

Abstract excerpt

Recent genome-wide meta-analyses identified 157 loci associated with cross-sectional lipid traits. Here we tested whether these loci associate (singly and in trait-specific genetic risk scores [GRS]) with longitudinal changes in total cholesterol (TC) and triglyceride (TG) levels in a population-based prospective cohort from Northern Sweden (the GLACIER Study). We sought replication in a southern Swedish cohort...

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Identifiers

PMID: 24922540
DOI: 10.1371/journal.pgen.1004388
PMCID: PMC4055682

Genes

APOA1
APOE
TRIB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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