Article
Higher chylomicron remnants and LDL particle numbers associate with CD36 SNPs and DNA methylation sites that reduce CD36.
Journal of lipid research - 1 Dec 2016
Love-Gregory Latisha, Kraja Aldi T, Allum Fiona, Aslibekyan Stella, Hedman Åsa K, Duan Yanan, Borecki Ingrid B, Arnett Donna K, McCarthy Mark I, Deloukas Panos, Ordovas Jose M, Hopkins Paul N, Grundberg Elin, Abumrad Nada A
Abstract excerpt
Cluster of differentiation 36 (CD36) variants influence fasting lipids and risk of metabolic syndrome, but their impact on postprandial lipids, an independent risk factor for cardiovascular disease, is unclear. We determined the effects of SNPs within a ∼410 kb region encompassing CD36 and its proximal and distal promoters on chylomicron (CM) remnants and LDL particles at fasting and at 3.5 and 6 h following a...
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