Article
Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype.
Acta neuropathologica communications - 18 Nov 2016
Moloney Christina, Rayaprolu Sruti, Howard John, Fromholt Susan, Brown Hilda, Collins Matt, Cabrera Mariela, Duffy Colin, Siemienski Zoe, Miller Dave, Swanson Maurice S, Notterpek Lucia, Borchelt David R, Lewis Jada
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder of upper and lower motor neurons. Mutations in the gene encoding the nuclear matrix protein Matrin 3 have been found in familial cases of ALS, as well as autosomal dominant distal myopathy with vocal cord and pharyngeal weakness. We previously found that spinal cord and muscle, organs involved in either ALS or distal myopathy, have...
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