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Article

Knockdown of genes involved in axonal transport enhances the toxicity of human neuromuscular disease-linked MATR3 mutations in Drosophila.

FEBS letters - 1 Sept 2020

Zhao Melody, Kao Ching Serena, Arndt Claudia, Tran David Duc, Cho Woo In, Maksimovic Katarina, Chen Xiao Xiao Lily, Khan Mashiat, Zhu Hongxian, Qiao Julia, Peng Kailong, Hong Jingyao, Xu Jialu, Kim Deanna, Kim Jihye Rachel, Lee Jooyun, van Bruggen Rebekah, Yoon Wan Hee, Park Jeehye

Abstract excerpt

Mutations in the nuclear matrix protein Matrin 3 (MATR3) have been identified in amyotrophic lateral sclerosis and myopathy. To investigate the mechanisms underlying MATR3 mutations in neuromuscular diseases and efficiently screen for modifiers of MATR3 toxicity, we generated transgenic MATR3 flies. Our findings indicate that expression of wild-type or mutant MATR3 in motor neurons reduces climbing ability and...

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Identifiers

PMID: 32515490
DOI: 10.1002/1873-3468.13858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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