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Article

Subcellular Localization of Matrin 3 Containing Mutations Associated with ALS and Distal Myopathy.

PloS one - 1 Jan 2015

Gallego-Iradi M Carolina, Clare Alexis M, Brown Hilda H, Janus Christopher, Lewis Jada, Borchelt David R

Abstract excerpt

BACKGROUND: Mutations in Matrin 3 [MATR3], an RNA- and DNA-binding protein normally localized to the nucleus, have been linked to amyotrophic lateral sclerosis (ALS) and distal myopathies. In the present study, we have used transient transfection of cultured cell lines to examine the impact of different disease-causing mutations on the localization of Matrin 3 within cells. RESULTS: Using CHO and human H4...

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Source

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Identifiers

PMID: 26528920
DOI: 10.1371/journal.pone.0142144
PMCID: PMC4631352

Genes

MATR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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