Article

Matrin 3-dependent neurotoxicity is modified by nucleic acid binding and nucleocytoplasmic localization

2018-02-20

Abstract excerpt

<h4>ABSTRACT</h4> Abnormalities in nucleic acid processing are associated with the development of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in Matrin 3 ( MATR3 ), a poorly understood DNA- and RNA-binding protein, cause familial ALS/FTD, and MATR3 pathology is a feature of sporadic disease, suggesting that MATR3 dysfunction is integrally linked to ALS pathogenesis. Using a...

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Literature Corpus work: 88707597-7363-5256-b5f3-e5bc674cc5d0
DOI: 10.1101/268458

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